Table 4

Biliary and intestinal excretion of paclitaxel in mdr1a/1b (+/+) and mdr1a/1b (−/−) mice with a cannulated gallbladder

mdr1a/1b (+/+)mdr1a/1b (−/−)
Biliary excretion (% of dose)5.9 ± 3.45.2 ± 2.9
Intestinal excretion (% of dose)3.5 ± 0.80.8 ± 0.4**
Plasma level (ng/ml) at 90 min289 ± 76313 ± 77
  • Female mice with a cannulated gallbladder and ligated common bile duct received an i.v. injection of paclitaxel (5 mg/kg). Bile was collected for 90 min. Intestinal contents and plasma levels were measured at the end of this period. Results are means ± SD (n = 4). **P < 0.002.