Table 3

Titers of antibodies against mBSA in sera

Source of seraAntibodies against mBSA in sera (mean ± SEM) OD405
Before7 days14 days
 ImmunizedIL-6 (+/+)0.109  ±  0.0090.750  ±  0.0791.294  ±  0.102
IL-6 (−/−)0.119  ±  0.010.476  ±  0.007*0.616  ±  0.031*
 Nonimmunized IL-6 (+/+)0.092  ±  0.0050.108  ±  0.040.110  ±  0.01
IL-6 (−/−)0.107  ±  0.0090.110  ±  0.0120.112  ±  0.013
  • Sera were collected before and 7 or 14 days after first immunization. The titers of antibodies against mBSA were measured by ELISA. ∗, P < 0.005, IL-6 −/− compared to IL-6 +/+.