Table 3

Programmed −1 ribosomal frameshifting and M1 virus maintenance of strains harboring multiple mutations of UPF genes

Genotype (strain)% ribosomal frameshifting*Killer maintenance
UPF+ (HFY1200)2.5+
upf3-Δ (HFY861)8.4
mof4-1 (HFY870mof4)7.0
mof4-1 upf3-Δ (HFY872mof4)8.0
upf1upf2-Δ (HFY3000)3.2+
upf1upf3-Δ (HFY872)7.2
upf2upf3-Δ (HFY874)9.2
upf1upf2upf3-Δ (HFY883)8.0
  • * Programmed −1 ribosomal frameshifting efficiency and M1 virus maintenance was determined as described in the legend of Table 2