Table 2

Genotype and allele frequency associations

A118G Genotypes TotalA118G Alleles TotalC17T Genotypes TotalC17T Alleles Total
A/AA/GG/GAGC/CC/TT/TCT
Ethnicity*
 African-American30 (0.968)1 (0.032)0 —3161 (0.984)1 (0.016)6221 (0.677)7 (0.226)3 (0.097)3149 (0.790)13 (0.210)62
 Caucasian41 (0.788)10 (0.192)1 (0.019)5292 (0.885)12 (0.115)10450 (0.962)2 (0.038)0 —52102 (0.981)2 (0.019)104
 Hispanic50 (0.746)15 (0.225)2 (0.030)67115 (0.858)19 (0.142)13462 (0.925)5 (0.075)0 —67129 (0.963)5 (0.037)134
χ(2)2=7.15 (P=0.028)χ(2)2=26.0 (P=0.000002)
Gender
 Female59 (0.855)8 (0.116)2 (0.029)69126 (0.913)12 (0.087)13858 (0.841)9 (0.130)2 (0.029)69125 (0.906)13 (0.094)138
 Male64 (0.771)18 (0.217)1 (0.012)83146 (0.880)20 (0.120)16677 (0.928)5 (0.060)1 (0.012)83159 (0.958)7 (0.042)166
χ(1)2 = 0.90 (P = 0.343)Yate’s corrected χ(1)2 = 2.53 (P = 0.112)
Opioid Dependence
 Dependent94 (0.832)18 (0.159)1 (0.009)113206 (0.912)20 (0.088)22697 (0.858)13 (0.115)3 (0.027)113207 (0.916)19 (0.084)226
 Nondependent29 (0.744)8 (0.205)2 (0.051)3966 (0.846)12 (0.154)7838 (0.974)1 (0.026)0 —3977 (0.987)1 (0.013)78
Yale’s corrected χ(1)2 = 1.98 (P = 0.159)Yate’s corrected χ(1)2 = 3.70 (P = 0.054)
  • * The two individuals who were not classified into African-American, Caucasian, or Hispanic ethnic groups were not included in the analysis.