Table 3

Toxicity of epothilone B and desoxyepothilone B in normal nude mice

GroupDose, schedule, and route of administrationMice, nMice that died, n
Control40
20.6 mg/kg, QD × 4, i.p.88*
425 mg/kg, QD × 4, i.p.60
  • * Mice died of toxicity on days 5, 6, 6, 7, 7, 7, 7, and 7.