Table 4

Therapeutic effect of desoxyepothilone B, epothilone B, paclitaxel, vinblastine, and camptothecin in nude mice bearing human MX-1 xenograft

DrugDose, mg/kgAverage body weight change, g Average tumor size, T/C Toxicity deathn
Day 711131517Day 11131517
Control27.2+0.8+1.1+1.9+0.61.001.001.001.000/88
41527.1+0.8+1.1+1.6+1.50.650.46*0.49*0.41**0/66
2527.0+0.4+0.7+1.0+0.70.38*0.11**0.05***0.04****0/66
20.326.9+0.5+0.4−0.3−1.21.000.710.710.840/77
0.627.4−0.3−1.3−2.1−2.11.080.730.810.743/77
Paclitaxel526.9−0.1+0.4+1.1+1.20.540.460.40*0.45**0/77
10§27.6−2.7−1.1−0.3+2.20.430.370.120.114/77
Vinblastine0.225.7+0.6+1.4+2.3+2.90.650.540.560.880/77
0.426.4+0.8+0.5+1.9+2.10.800.560.830.881/77
Campothecin1.527.4−0.9−0.7−0.4+1.00.610.45*0.32*0.36**0/77
  • MX-1 tissue, 50 μl/mouse, was implanted s.c. on day 0. Every other day in treatments were given on days 7, 9, 11, 13, and 15. The average tumor volumes of the control group on day 11, 13, 15, and 17 were 386 ± 120, 915 ± 245, 1,390 ± 324, and 1,903 ± 319 mm3 (mean ± SEM), respectively; *P < 0.05, **P < 0.01, ***P < 0.005, ****P < 0.001. 

  • One of six mice with no detectable tumor on day 35. 

  • Three mice died of drug toxicity on day 17. 

  • § Four mice died of drug toxicity on days 13, 13, 13, and 15. 

  • One mouse died of drug toxicity on day 15. 

  • P values were not shown because of toxic lethality.