Table 6

Therapeutic effects of desoxyepothilone B, Epo B, and paclitaxel in nude mice bearing SK-OV-3 tumors using different vehicles and different routes of administration

Drug/routeDose, mg/kgAverage body weight change, g Average tumor size, T/C Tumor disappearanceToxicity death
Day 1115171921Day 15171921
Control026.4−0.2−0.4+0.2+0.81.001.001.001.000/60/6
4/i.p.3527.8−1.7−2.1−2.1−2.40.570.330.350.280/60/6
4/i.v.1527.00−0.6−1.1−2.60.860.560.500.440/64/6*
2/i.v.0.627.0−0.9−0.5−3.3−3.40.750.690.880.770/60/6
Paclitaxel/i.p.527.4−1.1−2.0−1.0−0.60.690.600.490.400/60/6
Paclitaxel/i.v.1527.2−0.6−0.8−0.8−0.90.970.670.420.280/60/6
  • Fifty-microgram tumor tissue was implanted s.c. on day 0. Every other day i.p. or i.v. treatments were given on days 11, 13, 15, 17, and 19. The average tumor size of control group (right side) on day 15, 17, 21, and 23 was 170, 392, 659, 1,003, and 1,280 mm3, respectively. i.p. route used DMSO, and i.v. route used Cremophor + EtOH (1:1) as vehicles. 

  • * Four of six mice died of drug toxicity on days 23, 23, 23, and 25.