Table 4

The sample-based case-control design: Alleles from 3N/2 affected cases and 3N/2 hypernormal controls

Marker allele Total
MM*
Cases
 Observed number a b a + b = 3N
 Expected frequency Embedded Image Embedded Image 1/2
Controls
 Observed number c d c + d = 3N
 Expected frequency Embedded Image Embedded Image 1/2
Observed numbera + cb + d6N