Table 3

Mutation rates at the hom3-10 and lys2-Bgl hotspots

StrainMutation rate
hom3-10lys2-Bgl
T646–652A364–369C401–404T417–419
Wild type9.5  ×  10−9 (1.0)0.2  ×  10−8 (1.0)0.13  ×  10−8 (1.0)0.05  ×  10−8 (1.0)
mlh3 3.7  ×  10−8 (3.9)1.1  ×  10−8 (5.5)0.44  ×  10−8 (3.4)0.04  ×  10−8 (0.9)
msh3 N.D.1.1  ×  10−8 (5.5)0.18  ×  10−8 (1.4)<0.04  ×  10−8 (<1)
mlh3 msh3 N.D.1.4  ×  10−8 (7.0)0.5  ×  10−8 (3.8)0.15  ×  10−8 (3.0)
msh6 9.1  ×  10−8 (8.6)0.23  ×  10−8 (1.2)0.23  ×  10−8 (1.8)0.76  ×  10−6 (15.2)
mlh3 msh6 8.2  ×  10−7 (86)2.9  ×  10−8 (14.5)0.6  ×  10−8 (4.6)0.23  ×  10−6 (4.6)
  • Mutation rates were recalculated based on the frequency of occurrence of frameshifts at the indicated sites. N.D., not determined (see Table 2 for gross mutation rates at this site).