Table 1

Sequence variability among unique sequences at the flaA, flaB, and vacA loci in H. pylori from different sources

Gene, bpNo. of unique sequences, total% PolymorphicMean % Ka, rangeMean % Ks, range
H. pylori
vacA (444)
Canada33 (33)21.82.5 ± 1.114.1 ± 5.5
S. Africa21 (22)17.62.2 ± 1.614.7 ± 7.3
German families9 (14)12.82.2 ± 1.617.4 ± 4.7
All data63 (69)25.43.1 ± 1.816.8 ± 6.4
flaA (471)
Canada33 (33)17.00.5 ± 0.615.6 ± 3.9
S. Africa21 (22)10.80.03 ± 0.0813.2 ± 4.3
German families9 (14)9.80.1 ± 0.216.5 ± 3.9
All data63 (69)21.00.3 ± 0.515.6 ± 4.0
flaB (339)
Germany54 (54)18.90.3 ± 0.321.4 ± 6.4
S. Africa19 (22)15.30.4 ± 0.324.3 ± 10.4
German families9 (14)11.80.4 ± 0.520.8 ± 6.0
All data82 (90)22.40.4 ± 0.323.0 ± 7.4
D. melanogaster (Adh, Amy, Est6)0.2 (0.1–0.3)2.7 (2.1–3.3)
E. coli (putP, icd, mdh, trpC)0.2 (0.06–0.8)6.6 (4.1–9.7)
N. meningitidis (11 genes)0.7 (0.2–7.8)13.4 (5.9–26.8)