Table 2

Mean life span of a number of unc mutant strains

StrainGenotypenMeanDiff, %Significance level
Experiment no. 1*
 N2+5019.0  ±  0.5
 MQ545 unc-24(e138) 5019.2  ±  0.6+10.79
 MQ546 unc-24(e448) 5019.1  ±  0.4+10.85
 MQ547 unc-24(e927) 5019.0  ±  0.500.95
 MQ548 unc-24(e1172) 5019.7  ±  0.4+40.25
Experiment no. 2
 N2+5021.7  ±  0.6
 MQ613 unc-25(e265) 5022.8  ±  1.1+50.42
 MQ612 unc-25(e591) 5022.1  ±  0.9+20.71
 MQ611 unc-25(e891) 5022.5  ±  1.0+40.49
 MQ633 unc-49(e382) 5023.1  ±  0.6+70.11
MQ603 unc-79(e1068) 5024.1  ±  0.9+110.03
 MQ604 unc-80(e1069) 5021.6  ±  0.600.95
Experiment no. 3
 N2+5019.9  ±  0.5
MQ587 unc-25(e156) 5025.1  ±  0.7+26<0.0005
MQ592 unc-26(e205) 5028.7  ±  0.6+44<0.0005
MQ647 unc-26(e345) 3429.2  ±  0.8+47<0.0005
MQ574 unc-26(e1196) 5027.3  ±  0.7+37<0.0005
MQ648 unc-26(m2) 3926.8  ±  0.7+35<0.0005
MQ632 unc-30(e596) 5018.2  ±  0.5−90.02
Experiment no. 4
 N2+5021.6  ±  0.6
 MQ575 unc-30(e191) 5020.0  ±  0.6−70.06
MQ588 unc-30(e318) 5016.9  ±  0.5−22<0.0005
 MQ578 unc-46(e177) 5021.5  ±  1.000.96
 MQ579 unc-47(e367) 5020.5  ±  0.5−50.16
Experiment no. 5
 N2+5019.9  ±  0.7
 MQ636 unc-79(e1030) 3819.1  ±  0.7−40.43
 MQ635 unc-79(qm12) 5019.7  ±  0.5−10.89
 MQ634 unc-79(qm14) 5021.9  ±  0.8+100.05
 MQ638 unc-80(e1272) 5022.0  ±  0.7+110.03
 MQ608 unc-80(qm2) 5021.2  ±  0.7+70.18
 MQ609 unc-80(qm3) 5020.1  ±  0.6+10.83
 MQ637 unc-80(qm9) 5019.5  ±  0.6−20.67
  • Columns are as described for Table 1. Before outcrossing all of the strains listed above, a number of other unc strains received from the Caenorhabditis Genetics Center or Medical Research Council (United Kingdom) also were tested. From these studies we found that mutations in the genes unc-1, -4, -6, -7, -9, and -29 do not affect life span (unpublished data). 

  • * unc-24 alleles have been tested four times with similar results.