Table 1

Effect of MTHFR genotype on RBC folate content and relative folate form distribution

MTHFR genotypeTotal folate, nmol/g hemoglobinNumber of samples with formylated THFFormylated THF, percent of totalMethylated THF, percent of total
C/C3.05  ±  1.010/80100
T/T2.98  ±  0.958/10*29 ± 22* 71 ± 22*
  • Values represent mean ± SD. 

  • Total folate concentrations represent the sum of the individual folate form concentrations obtained by chromatography. 

  • * Statistically significant difference (P < 0.001) between genotypes by using Mann–Whitney U test.