Table 1

Influence of peptides on the chaperone activity of Hsp90 fragments

PeptideSequenceTurbidity
N210262C
No peptide3030
HD 25SGFTFND35n.d.
HD 86LRAEDMA39n.d.
HD 131GPSVFPL5358
HD 131 LGPSVFPLAPS SKC9556
HD 132PSVFPLA3860
HD 133SVFPLAPS5558
HD 131 + HD 133GPSVFPL + SVFPLAPS51n.d.
HD 167WNSGALT34n.d.
GR 1AKAILGLRNL HLDDQMTLL9260
GR 3AKAILGLRN7655
GR 4LRNLHLDDQ6562
GR 5LHLDDQMTLL4654
GR 3 + GR 5AKAILGLRN + LHLDDQMTLL80n.d.
VSV 8RGYVYQGL7153
  • Aggregation of insulin was measured as described above. The numbers represent the normalized turbidity in arbitrary units determined 35 min after reduction of insulin. 

  • n.d., not determined.