Table 1

Effect of DHEA (100 nM) on neurotoxicity induced by either AMPA or kainic acid

Neurons per field, mean ± SEM
Control (no toxin + vehicle)26.9  ±  1.1
AMPA 25 μm + vehicle4.7  ±  0.4
AMPA + DHEA 100 nM15.0  ±  0.8*
Kainic acid 1 mM + vehicle7.1  ±  0.5
Kainic acid + DHEA 100 nM17.0  ±  0.5*
  • The effects of adding DHEA (100 nM) 6 h before either AMPA (25 μM) or kainic acid (1 mM) for 60 min on the mean number of neurons per field (four experiments for each treatment; 4-6 wells per experiment). 

  • * P < 0.001 (t test; toxin + vehicle vs. toxin + DHEA).