Table 3

Net reaction balance equations and functional attributes of basis pathways used to span the null space of the red blood cell stoichiometric matrix

Basis pathwayNet reaction equationPrimary functional attribute
p1glucose + 2 Pi + 2 ADP → 2 lactate + 2 ATPATP energy production for metabolic energy
p2glucose + 2 NAD+ → 2 pyruvate + 2 NADH + 2 H+NADH energy production for methemoglobin reduction
p3glucose + 2 Pi + 2 ADP + 2 NAD+ → 2 pyruvate + 2 ATP +2 NADH + 2 H+ATP production for metabolic energy and NADH production for methemoglobin reduction
p4glucose + 2 ATP + 2 NAD+ → 2 23DPG + 2 Pi + 2 ADP +2 NADH + 2 H+2,3-DPG production for oxyhemoglobin modulation
p5glucose + ATP + 2 NADP+ → R5P + CO2 + ADP + 2 NADPH + 2 H+Ribose 5-phosphate production for adenosine salvaging
p6glucose + 12 NADP+ → 6 CO2 + 12 NADPH + 12 H+NADPH energy production for glutathione reduction and subsequent antioxidant activity
p7–p22(no net reaction)(none)