Table 2

Gene frequencies in heterophile antibody-positive and-negative members of families with type 1 diabetes

GenesHeterophile antibody +Heterophile antibody −Control populationP
DQB1*0602
 Relatives10/29  (34.5%)28/207  (13.5%)25.0%<0.008
 CR pedigree5/9 (55.6%)3/36 (8.3%)<0.004
CTLA4 (G/G)
 Relatives6/29 (20.7%)22/159 (13.8%)12.8%NS
 Relatives + diabetics9/35 (25.7%)35/258 (13.6%)12.8%<0.03
Diabetes genotypes for relatives
 DQB1*030212/29 (41.4%)84/207 (40.6%)15.0%NS
 DQB1*0201/02015/29 (17.3%)32/207 (15.5%)5.7%NS
 INS(+/+)21/29 (72.4%)126/173 (72.8%)61.0%NS
  • The CTLA4 and insulin gene polymorphisms were analyzed as described (12, 13). HLA-DQB1 alleles were determined as described (13). NS, not significant. 

  • Statistical significance was determined by a two-tailed χ2 test. 

  • Statistical significance was determined by a Fisher’s exact test.