Table 1

The yields of parent and D199A mutant virus at 20 hr after infection of various cell lines at multiplicities of infection shown

Cell linePFU/cellYield (×105)*
HSV-1(F)R7914
Vero5.0300310
0.05680730
HEp-25.0100190
0.0569800
RSC5.03,400560
0.051,600420
HeLa5.01,8006,500
0.057.79.8
  • * Virus yields were determined by standard plaque assays in Vero cells.