Table 1

Summary for ku86−/− (mt) and control (con) mice

GenotypeAge, wkOsteopeniaEpiphysis closureSkin and follicular atrophyALT,* units/literInclusionsReactive immune responseNodular hyperplasia§
mt1–150/30/60/457 ± 10/70/70/7
con0/50/70/756 ± 170/120/120/12
mt22nd2/2ndndndndnd
connd0/2ndndndndnd
mt31–503/31/13/381 ± 42/41/52/4
con0/40/10/4400/40/40/4
mt51–70ndndnd93 ± 303/82/75/8
conndndnd38 ± 60/90/91/9
mt>70ndndndnd1/10/11/1
con4/54/48/8126 ± 1096/2319/239/23
  • The number of mice affected (left) compared to the total number observed (right). nd, not done. 

  • * Number observed: for ku86−/− at 1–15 wk, 3; 31–50 wk, 3; 51–70 wk, 6 and for control at 1–15 wk, 6; 31–50 wk, 1; 50–70 wk, 6; >70 wk, 11. 

  • Cytoplasmic hepatocellular inclusions observed for all ku86−/− mice and four control mice, nuclear hepatocellular inclusions observed for two control mice. 

  • Includes microabscesses (acute response with neutrophils) and granulamatous inflamation (chronic response with mononuclear cells) observed in the liver. 

  • § Nodules were grossly observed in seven livers from control mice and in two livers from ku86−/− mice, the remainder could only be observed by histology (micronodular).