Table 1

Mean (± SEM) percentage of total time in each sleep stage determined during the second and third hour postdose using area under the curve calculations

Sleep stageControl10.0 (μg/rat ICV), n = 9
Arousal13.4  ±  4.9%34.5  ±  8.7%*
Paradoxical sleep5.9  ±  1.8%1.9  ±  0.9%
SWS113.1  ±  1.8%13.0  ±  2.9%;  NS
SWS267.6  ±  5.9%50.7  ±  8.2%;  NS
  • NS, nonsignificant. SWS, slow wave sleep. 

  • * Increased relative to vehicle, P < 0.05. 

  • Decreased relative to vehicle, P < 0.05.