Table 2

Effects of orexin A on neuroendocrine markers

MarkersDose of orexin A (μg/rat ICV)
Control0.31.03.010.030.0
Prolactin, ng/ml4.84  ±  1.41.08  ±  0.86*ND < 0.1*ND < 0.1*ND < 0.1*ND < 0.1*
Growth hormone, ng/ml29.8  ±  12.537.9  ±  8.989.6  ±  2.9*3.8  ±  0.95*3.5  ±  1.09*1.7  ±  0.29*
Corticosterone, ng/ml44.0  ±  8.9938.8  ±  5.774.6  ±  13.0260.3  ±  14.7104.2  ±  24.8*140.5  ±  21.1*
Thyroid-stimulating hormone, ng/ml6.8  ±  1.747.9  ±  0.956.6  ±  0.716.1  ±  1.307.6  ±  1.32NA
  •  NA, experiment not done; ND, below limit of detection. ∗, P < 0.05 c.f. vehicle.