Table 4

Number of AML cases and controls, expected MTHFR 677/1298 allele and frequencies, adjusted ORs and 95% CIs by MTHFR 677 and MTHFR 1298 using MTHFR 677CC and MTHFR 1298AA as a reference

MTHFR 677MTHFR 1298Cases, n = 211Controls n = 356OR*95% CIExpected frequency of MTHFR 677/1298 in controls
CCAA39  (18.5)58  (16.3)1(24.2)
CCAC66  (31.3)95  (26.7)0.90(0.52, 1.56)(23.0)
CCCC20  (9.5)36  (10.1)0.82(0.41, 1.64)(5.8)
CTAA33  (15.6)65  (18.3)0.66(0.35, 1.23)(16.1)
CTAC27  (12.8)60  (16.9)0.60(0.31, 1.18)(15.3)
CTCC3  (1.4)2  (0.6)1.95(0.30, 12.7)(3.9)
TTAA20  (9.5)37  (10.4)0.72(0.35, 1.47)(5.3)
TTAC3  (1.4)3  (0.8)2.29(0.34, 15.3)(5.1)
TTCC0 0 (1.3)
SNA2621
  • Test for interaction: χ2 = 4.25 (P = 0.37). 

  • * OR of combined MTHFR 677/1298 genotypes with 677CC/1298AA as a reference was estimated using conditional logistic regression. 

  • Expected MTHFR 677/1298 allele frequencies calculated by multiplying observed MTHFR 677 and 1298 control frequencies. 

  • Sample not available or did not amplify.