Table 1

Neurobehavioral effects of Abn-CBD and THC in the mouse model of cannabinoid activity

TreatmentLocomotor activity, % inhibitionAntinociception, % MPECore temp, Δ°CRing immobility, %
Vehicle0  ± 06  ± 30.5  ± 0.10  ± 0
Abn-cbd (60 μg/g)6  ± 1613  ± 3−0.5  ± 0.90  ± 0
THC (3 μg/g)79  ± 6**92  ± 8**−4.5  ± 0.5**34  ± 5*
  • Responses were expressed as described in Materials and Methods, MPE, maximal possible effect. Means ± SE from 6–12 independent experiments are shown. Significant difference from corresponding responses in vehicle-treated mice: *, P < 0.05; **, P < 0.005.