Table 1

Tpk2 regulates the high-affinity iron-uptake pathway

GeneFunction
High-affinity iron uptake
 Fre1Ferric reductase, plasma membrane
Fre2Ferric reductase, plasma membrane
Fet3Multicopper ferroxidase, plasma membrane
Ftr1Iron permease, plasma membrane
Ccc2Copper transporter
Low-affinity iron uptake
 Fet4Low-affinity Fe(II) transporter
Vacuole iron transport
 Fth1Vacuolar iron transporter, FTR1 homolog
 Fet5Multicopper oxidase, vacuole
Mitochondrial iron homeostasis
 Atm1ABC transporter, mitochondria
 Yfh1Yeast frataxin homolog
Putative iron transporters
Sit1Siderophore iron transport
Arn1MFS/MDR family
Yol158cMFS/MDR family
Yhl047cMFS/MDR family
  • Proteins involved in iron transport are listed above. Those shown in bold are negatively regulated by Tpk2. ABC, ATP-binding cassette; MFS/MDR, major facilitator super family/multidrug resistance.