Table 2

Predominant amino acids at selected positions in N1 neuraminidase proteins

StrainAmino acid position*
7477798184188264267285287307344352
AvianF/LEAATIVVAENYK
Sw/Eng/92FETVKIVVSENNK
Brevig/18VGDTIMTITKDNR
Human, oldVGDTIMTITKDNR
Swine, oldIGDTIMIITKDNR
Human, newVGDTTMTITTNDR
Swine, newIGDTIMIITKDNR
Location:StStStStSISSSISIS
  • * Amino acid numbering is aligned to the N1 NA of A/NJ/8/76 (H1N1). 

  • Predominant amino acid residues are shown for avian strains, 1930s H1N1 strains (old human and old swine), and recent H1N1 strains (new human and new swine). 

  • Theoretical structural location on N1 as aligned to N9 crystal structure by using the rasmol program (29). St, stalk; S, surface of globular head; I, buried internally in globular head.