Table 1

Effect of EBA-175 truncation on invasion phenotypes

StrainRelative invasion (percent of control)
NeuraminidaseTrypsinNeuraminidase + trypsin
W2-mef0.062.0  ± 14.40.0
W2-m/Δc.183.2  ± 11.159.9  ±  7.00.0
W2-m/Δc.285.7  ±  2.073.7  ±  9.10.0
  • Values are the percent invasion rates relative to invasion in normal, untreated cells and represent the average of two independent assays, each performed in triplicate. Values for re-invasion into normal, untreated cells ranged from 3.8–5.5% parasitaemia as compared to 0–0.3% for background controls.