Table 1

Some representative mammalian peptides

PeptideClassAmino acid sequence*
HNP-1 (α-defensin)β-sheetAC1YC2RIPAC3IAGERRYGTC3IYQGRLWAFC2C1
HBD-2 (β-defensin)β-sheetMRVLYLLFSFLFIFLMPLPGVFGGIGDPVTC1LKSGAIC2HPVFC3PRRYKQIGTC2GLPGTKC1C3KKP
Protegrinβ-sheetRGGRLC1YC2RRRFC1VC2VGR
IndolicidinExtendedILPWKWPWWPWRR-NH2
Bac5ExtendedRFRPPIRRPPIRPPFYPPFRPPIRPPIFPPIRPPFRPPLGPFP
BactenicinLoopRLC1RIVVIRVC1R
LL-37α-helicalLLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
Cecropin P1α-helicalSWLSKTAKKLENSAKKRISEGIAIAIQGGPR
  • * Single-letter amino acid code. 

  • Subscript numbers represent amino acids that are joined by cysteine disulfides.