Table 2

Thermodynamics of the CD4-gp120 interaction at 37°C by isothermal titration calorimetry

ΔG°, kcal/molΔH°, kcal/molTΔS°, kcal/molΔC°, kcal/mol/KKD, nM
WD61 full-length gp120−11.8  ± 0.3−63  ± 351.2  ± 3−1.2  ± 0.25  ± 3
Core gp120−9.5  ± 0.1−62  ± 352.5  ± 3−1.8  ± 0.4190  ± 30