Table 3

Genes correlated with the development of hyperglycemia

Accession no.Descriptionr value FoldAccession no.
Descriptionr value Fold
Signal transduction
Transcription factors
M34397IL-3 receptor-like protein−0.955−3.5W87135Single stranded DNA binding protein p90.9732.2
 aa097386Similar to CAM-like protein kinase−0.982n/a  af003866Pale ear (ep wild type allele)−0.982−2.1
U58889SH3-containing protein (SH3P3)−0.970n/a AB001990Dcra−0.985−1.4
 u35124Nonreceptor tyrosine phosphatase−0.968n/a  m11943Int-1 proto-oncogene0.9564
 d31943Cytokine inducible SH2-containing protein−0.971−2.2 u67840Dlx5−0.988n/a
 u60528Guanylin precursor gene0.963n/a Z32675Hairless protein−0.956−1.9
 aa217487Similar to mouse pim-1 protein kinase−0.972n/a AJ002366Transcription factor TFIIH, 62 kD subunit−0.968
n/a
 m64689flk-20.972n/a U41285Dishevelled-3 (Dvl-3)−0.951−1.5
C79373Similar to phosphatase inhibitor-20.9521.5L38607BF-2 transcription factor0.994n/a
 aa105135Similar to P53-binding protein−0.982−2.4 aa710439BACH1−0.986n/a
 aa467011Similar to LMW G-protein0.955n/a W83286Similar to H. sapiens RNA polymerase II0.9671.4
 d83266vav-T−0.958n/a D14336RNA polymerase I associated factor−0.972−1.5
W91283Similar to human ras-like protein0.9891.6Others
C81377Similar to rat activated c-raf oncogene0.960n/a  aa711217Similar to NADH-ubiquinone oxidoreductase0.9601.4
 u70324Fyn(T)0.965n/a  aa521794Similar to cytochrome c oxidase−0.961−1.6
X72862β-3-adrenergic receptor0.951n/a  iM36660NAD(P)H menadione oxidoreductase−0.958n/a
 101695Calmodulin-dependent phosphodiesterase−0.960−1.2 af015284Selenoprotein W (mSelW)−0.992n/a
 x04648IgG1/IgG2β Fc receptor (FcR)−0.961−3.3M99054Acid phosphatase type 5 gene−0.960−1.5
Secreted aa543785Thymic dendritic cell-derived factor 10.9851.5
M33960Plasminogen activator inhibitor (PAI-1)0.9622.2J02809Neural specific calmodulin-binding protein−0.954n/a
D38580VNSP I(vomeronasal secretory protein I)−0.962n/a  aa061099Ribonuclease HI−0.980−3.3
Protein synthesis and processingC78741Poly(A) binding protein II (mPABII)−0.951−1.4
 aa036204Similar to human 40S ribosomal protein S240.9711.7AA230943Similar to mouse Sm-B−0.952−2.1
D1290747-kDa heat shock protein (HSP47)−0.966−1.6 aa544831Similar to renin-binding protein−0.973−2.5
 125913Chaperonin0.9991.5U12564129 defensin-like gene 4C-20.971n/a
C77806Similar to rat carboxypeptidase B gene−0.960n/a  c79315Similar to M. musculus tex2920.9711.6
 aa270493Similar to deoxyhypusine synthase−0.959−2.4L06234Dihydropyridine-sensitive calcium channel−0.969n/a
 aa611449Similar to Homo sapiens HSPC183−0.962−2.6U62021Neuronal pentraxin 1 (NPTX1)−0.951−2.1
AA105758MDj10−0.974−2.2 aa560507Similar to antiquitin−0.984−1.6
Cytoskeletal and ECM z72000BTG30.9592.1
M25825tctex-1−0.959−1.9 af003346Ubiquitin-conjugating enzyme UbcM20.9821.7
C77864Similar to Chinese hamster for β tubulin−0.991n/a AA072822Testosterone 15-α-hydroxylase−0.957n/a
 aa111610Similar to tuftelin-interacting protein 100.950n/a  aa547057Similar to HT Protein−0.979−1.4
AA138226Similar to rat clathrin light chain (LCB3)0.9561.1Metabolism
 m75720α-1 protease inhibitor 30.955n/a AA146156Keratinocyte lipid binding protein (Klbp)0.9868.6
C76274Similar to Mus musculus ligatin (Lgtn)−0.952n/a AA120674Similar to Homo sapiens acylphosphatase 20.9642.3
 aa204573Similar to human spindle pole body protein−0.972−1.5U21489Long-chain acyl-CoA dehydrogenase−0.963−1.6
 aa592828Aldo-keto reductase AKR1C10.9772.2
 ET63206Fructose-1,6-bisphosphatase0.960n/a
  • r values were calculated using the rank order of the five sets of animals with increasing hyperglycemia. Fold changes represented by n/a mean that the mRNA level increased from, or decreased to, an expression level outside the linear range of detection.