Table 1

Genes with decreased expression with obesity in each mouse strain

Accession no.Description FoldAdipogenesisAccession no.
Description FoldAdipogenesis
Hormones and signal transductionTranscription factors
 x72862β-3-adrenergic receptor−10.5IncreaseAA068578add1/SREBP−2.7Increase
 aa500440GTP-binding protein (Gαi-1)−2.3DecreaseSecreted proteins
 aa529056Guanine nucleotide binding protein 11−1.6AA106347Angiotensinogen precursor−8.1Increase
 u02602Thyroid stimulating hormone receptor−1.5W36455Adipsin−8.3Increase
X61431Diazepam-binding inhibitor−2D00466Apolipoprotein E gene−2.4
AF009246Ras-related protein (DEXRAS1)−2.9 m60579Complement component C2−3.2
MitochondrialOthers
 aa245912Similar to succinate dehydrogenase−2U63146Retinol-binding protein (RBP)−2.5Increase
 aa466050Similar to cytochrome c1−1.8AA049662Retinol-binding protein (RBP)−2.2Increase
 aa667872Similar to ubiquinol-cytochrome c Reductase core protein 2−3.4W14367Retinol-binding protein (RBP4)−1.8Increase
 aa733351Similar to ATP synthase E chain−2.1AA154594Similar to branching enzyme−2.6
W42043Branched-chain amino acid aminotransferase−2.8W85270Inorganic pyrophosphatase−2
W41817Cytochrome c oxidase, subunit VIIIa−2.7W13498Glycogen phosphorylase−2.5
U07235Aldehyde dehydrogenase (ALDH2)−3AF012431D-dopachrome tautomerase (Ddt)−1.9
D16215Flavin-containing monooxygenase−2.8L31783Uridine kinase−2.7
 aa270965Mitochondrial enoyl-CoA hydratase−2.8U38940Asparagine synthetase−4
M60798SOD-1−2.2X51703Ubiquitin−2.7
Lipid metabolism aa688469Osteogenesis imperfecta (oim)−3.3
D29016Squalene synthase−1.8 ab004048Neuronatin−2.8
 aa271471ATP citrate-lyase mRNA−2.9Increase m30844B2 protein−11.2
 d50430Glycerol-3-phosphate dehydrogenase−2.5IncreaseU19596Cdk4 and Cdk6 inhibitor p18−2.7
X51905Lactate dehydrogenase-B−3.3IncreaseX14061β-globin complex−2.6
M21285Stearoyl-CoA desaturase−2.5IncreaseW82026Scr3, ssRNA BP−2.1
 109192Pyruvate carboxylase−2.1IncreaseW83919Elongation factor Tu−2.3
Y00516Aldolase A−2.5IncreaseM73483Glutathione S-transferase−5.8
AA080172Phosphoenolpyruvate carboxykinase−5.3IncreaseM96827Ob/ob haptoglobin−2.1
W295623T3-L1 lipid binding protein−2.3IncreaseAA059700β-2 microglobulin (B2m)−3.2
X95279Spot14−4.6Increase ET61037TI-225−2.5
 aa197973Similar to biotin carrier protein of methylmalonyl-CoA carboxyl-transferase−2.4
  • Fold changes are approximate, as the level of gene expression may have been outside the linear range of detection in one of the comparisons. Genes listed as “similar to” show sequence similarities with E < 5 × 10−5 (40). Changes in gene expression during adipocyte differentiation are listed when known (15).