Table 1

Frequency analysis of OspA-tetramer-binding CD4+ cells in patients with treatment-resistant Lyme arthritis and in healthy subjects

Lyme arthritis Controls
DRB1*0401+DRB1*0401DRB1*0401+
SubjectSynovial fluid Peripheral blood SubjectSynovial fluid Peripheral blood SubjectPeripheral blood
% OspA- tetramer% Control-tetramer% OspA- tetramer% Control-tetramerAg-Rx clones% OspA- tetramer% Control-tetramer% OspA- tetramer% Control-tetramerAg-Rx clones% OspA- tetramer% Control-tetramerAg-Rx clones
 2*3.050.250.010.01+12<0.0050.010.010.010110.02<0.0050
80.520.020.04<0.005NA16NANA0.050.01017<0.005<0.005NA
140.01<0.005<0.005<0.0050
3NANA0.110.08+
5NANA0.050.09+
10NANA<0.0050.010
  • Ag-Rx clones, + or 0 indicates whether antigen-reactive T cell clones could or could not be generated by single-cell cloning of tetramer-binding T cells, respectively. NA, not analyzed. 

  • * Subject is homozygous for HLA-DRB1*0401.