Table 2

Cardiac weights and echocardiographic measurements in lean (+/+) and obese (fa/fa) ZDF rats at 20 weeks of age

RatsnWeights Echocardiography
Body weight, gHeart weight, gRV weight, gLV weight, gLV end-diastolic diameter, mmLV end-systolic diameter, mmSeptal wall thickness, mmPosterior wall thickness, mmFractional shortening, %Fractional area shortening, %
Lean wild type (+/+)3394  ±  61.20  ± 0.010.20  ± 0.010.85  ± 0.017.3  ± 0.34.2  ± 0.41.6  ± 0.11.9  ± 0.143  ± 665  ± 8
Obese ZDF (fa/fa)8572  ± 24*1.55  ± 0.170.25  ± 0.021.06  ± 0.017.8  ± 0.75.0  ± 0.8*1.6  ± 0.11.7  ± 0.236  ± 7*56  ± 9*
TGZ-treated (fa/fa)6611  ±  71.78  ± 0.290.24  ± 0.021.04  ± 0.027.6  ± 0.54.0  ± 0.61.6  ± 0.11.8  ± 0.248  ± 769  ± 7
  • RV, right ventricle; LV, left ventricle. 

  • *P < 0.05, untreated obese (fa/fa) vs. lean (+/+) rats. 

  • P < 0.05, TGZ-treated obese (fa/fa) vs. untreated obese (fa/fa) rats.