Table 1

Normal induction of the generalized Shwartzman reaction in Tg mice

LPS, μg Anti-NK1.1-treated WTWT (dead/tested)Tg
Challenging*
1001 /90 /5
2001 /63 /64 /6
3002 /615 /1614 /17
  • * Mice were first primed with the footpad injection of 5 μg of S. marcescens-derived LPS 24 hr before i.v. injection of indicated challenging doses of LPS. 

  • Mice were treated twice with 100 μl of anti-NK1.1 ascites fluid 4 and 1 days before the priming injection.