Table 2

The ALR genome provides dominant protection from the adoptive transfer of diabetes by NOD bone marrow

Marrow donorRecipient (1,200 rad treated)IDDM 20 weeks after reconstitution, %Insulitis index (max = 1)Splenocytes, %
CD8+CD4+CD3+DbDdx
NODNOD1001.0010.2  ± 2*27.8  ± 5*38  ± 6*100  ± 00  ± 0
NODALR00.107.8  ± 2*30.0  ± 3*38  ± 4*96  ± 20  ± 0
NOD(ALR × NOD) F100.098.8  ± 1*27.4  ± 1*36  ± 1*96  ± 11  ± 1
NOD(NOD × ALR) F100.129.4  ± 1*28.4  ± 1*38  ± 1*98  ± 11  ± 1
ALRALR002.9  ± 113.6  ± 117  ± 10  ± 099  ± 0
ALRNOD005.3  ± 123.0  ± 128  ± 22  ± 098  ± 0
  • Data shown are mean ± SD. n = 5 for all experiments. Means with different symbols (*, †, ‡) within a column are significantly different at P < 0.05. Means with the same symbol are not significantly different.