Table 3

The ALR genome provides dominant protection from the adoptive transfer of diabetes by NOD.AI4 bone marrow

Marrow donorRecipient (1,200 rad treated)IDDM 20 weeks reconstitution, %Insulitis index (1 = max)Splenocytes, %
CD8+CD4+TgCD8+TgCD4+
NOD.AI4NOD1001.0015.4  ± 1*26.1  ± 3*70  ± 5*87  ± 6*
NOD.AI4ALR00.107.2  ± 117.2  ± 199  ± 162  ± 6
NOD.AI4(ALR × NOD)F100.158.6  ± 119.0  ± 192  ± 328  ± 1
NOD.AI4(NOD × ALR)F100.207.4  ± 219.0  ± 272  ± 1*21  ± 1§
  • Data shown are mean ± SD. n = 5 for all experiments. Means with different symbols (*, †, ‡) within a column are significantly different at P < 0.05. Means with the same symbol are not significantly different.