Table 2

The antiviral effects of ribavirin can be directly attributed to lethal mutagenesis

Normal100 μM ribavirin400 μM ribavirin1,000 μM ribavirin
RNA-specific infectivity loss3.318140
Loss of total viral RNA616
Total predicted titer reduction13.31002,200
Actual titer reduction*13.2712,000
  • * Untreated (“normal”) poliovirus titer in this experiment was 1.2 × 1010 PFU per plate of HeLa cells (6 × 106 cells). Data are the average of three experiments.