Table 1

Blood glucose, plasma insulin, and body weights in transplant recipients during the pre- and posttransplantation periods

Islet donorTx recipientBlood glucose, mg/dl Plasma insulin, ng/ml Body weight, g
Pre-TxPost-TxPre-TxPost-TxPre-TxPost-Tx
WTWT112.9  ± 3.9118.6  ± 3.91.67  ± 0.21.9  ± 0.227.5  ± 0.3529.66  ± 0.37
WTDH119.5  ± 3.1118.1  ± 4.04.55  ± 0.6*8.0  ± 1.6*26.4  ± 0.4*27.82  ± 0.34*
WT ob/ob 181.1  ± 19.5*145.6  ± 5.3*42.5  ± 5.7*42.3  ± 4.9*58.1  ± 1.09*68.2  ± 1.35*
DHWT128.3  ± 9.9134.2  ± 7.52.1  ± 0.462.6  ± 0.528.82  ± 0.4230.27  ± 0.28
DHDH146.4  ± 10.5133.4  ± 9.37.9  ± 1.4*11.6  ± 1.6*26.77  ± 0.4*28.55  ± 0.39*
  • Blood glucose levels were significantly higher in the ob/ob recipient mice compared with the WT and DH groups in the pre- and post-Tx periods; *, P < 0.001 ob/ob vs. WT or DH. In the pre-Tx and post-Tx states, the plasma insulin levels of the DH and ob/ob mice receiving WT islets were significantly higher than controls. *, P < 0.001, WT vs. DH or ob/ob;  

  • , P < 0.01, pre-Tx vs. post-Tx. Similarly, DH mice receiving DH islets showed significantly higher insulin levels than WT recipients. *, P < 0.01 WT vs. DH. The body weights of the DH mice were lighter than the WT controls, whereas the ob/ob mice were significantly heavier than both the WT and DH groups in the pre-Tx and post-Tx periods; *, P < 0.05 WT vs. DH or ob/ob., ‡, P < 0.05 pre-Tx vs. post-Tx. Post-Tx values were obtained eight weeks after transplantation. All values are means ± SEM. WT, n = 6–19; DH, n = 5–21; ob/ob, n = 9–21.