Table 1.

Biodistribution of ChimeriVax-WN02 and YF-VAX in tissues of cynomolgus monkeys by day after inoculation

TissueDay 3
Day 7
Day 14
Day 46
CV-WN n = 4
YF n = 4
CV-WN n = 5
YF n = 5
CV-WN n = 5
YF n = 5
CV-WN n = 5
YF n = 5
PosEq/mlPosEq/mlPosEq/mlPosEq/mlPosEq/mlPosEq/mlPosEq/mlPosEq/ml
Skin
    inoc3376, 408, 2850178011260000
    contra00000000
Spleen000459, 176, 234, 2570347, 69, 39100
Lymph N
    Axillary1110124612422102, 1670110900
    Mandib2301,96301281249, 1640000
    Mesen013381871970384, 86, 19900
Thymus000136320000
Bone marrow01751650252, 1410000
Liver0001340000
Heart00000000
Kidney13990000000
Pancreas00000000
Adr gland0001250000
Skel muscle00000000
Brain00000000
  • CV-WN, ChimeriVax-WN02; YF, yellow fever 17D; Pos, number monkeys positive by PCR; Eq/ml, plaque-forming equivalents per ml; inoc, inoculation site; contra, contralateral arm; mandib, mandibular; mesen, mesenteric; skel, skeletal.