Table 1

Pharmacological profile of human TA1

CompoundKi, nMEC50, nM
β-PEA8.0  ± 3.2324  ± 110
Tyramine34  ± 11214  ± 67
Dopamine422  ± 116,700  ± 1,700
Octopamine493  ± 994,029  ± 75
Tryptamine1,084  ± 159>6 uM
Histamine3,107  ± 1,593>5 uM
Serotonin>6 uM>10 uM
Norepinephrine>10 uM>5 uM
  • Values represent the average ± SEM from n ≥ 3 experiments. Binding Kis were determined from displacement of [3H]tyramine (20 nM) and EC50 values were determined by increases in cAMP accumulation.