Table 1

Muscle weights, mg

Transgenic animalsPectoralisTricepsQuadricepsGastrocnemius/ plantaris
Male controls (7 mo, n = 10)100.8  ± 5.4 115.6  ± 5.5 243.8  ± 12.5168.1  ± 7.6
Dominant-negative Act RIIB (7 mo)
 C5 male founder148155318252
 C11 male founder227250454338
 C33 male founder158176352244
 C42 male founder196212309269
Female controls (7 mo, n = 10)68.9  ± 2.796.9  ± 3.5208.3  ± 7.1140.3  ± 4.3
Dominant-negative Act RIIB (7 mo)
 C2 female founder104163352263
 C4 female founder103139303194
 C27 female founder135117181256
Male controls (4 mo, n = 12)98.3  ± 3.3110.9  ± 2.9251.7  ± 8.5169.3  ± 4.7
Follistatin (4 mo)
 F3 male founder296494736568
 F66 male founder169263421409
  • All animals (including controls) represent hybrid SJL/C57BL/6 F0 mice born from injected embryos.