Table 2

ED50 values for the behavioral effects of THC in FAAH+/+ and FAAH−/− mice [mg/kg (95% confidence limits)]

HypomotilityAntinociceptionHypothermia
FAAH+/+13 (10–17)13 (7–26)12 (9–17)
FAAH−/−13 (9–18)12 (7–20)15 (10–24)
  • FAAH+/+ and FAAH−/− mice were injected with 5, 10, 20, or 40 mg/kg THC (i.p.) and tested as described in Materials and Methods. The highest dose of THC failed to elicit more than 50% catalepsy in either genotype. n = 6–8 mice per group.