Table 1

Incidence of gastric tumors induced by NMBA in wild-type and Fhit-deficient mice

GenotypeTotal tumorsTumor-bearing miceTumors/mouse
+/+31/13 (7.7%)0.2
+/−5518/23 (78.3%)2.4
−/−12534/38 (89.5%)3.3
  • A total of 74 B6129F1–F4 mice (7–10 months of age) were given an intragastric dose of NMBA, 2 mg/kg body weight. All of the mice were killed 29 weeks after the NMBA dose. Tumor incidence was analyzed by two-tailed Fisher's exact test: +/− vs. +/+, P = 6.4 × 10−5; −/− vs. +/+, P = 1.3 × 10−7; +/− vs. −/−, P = 0.3.