Table 1

Exon and intron sizes for the TOP1 (nuclear) and TOP1mt (mitochondrial) genes

Number of exons Exon sizes Homology, %Intron phase Intron sizes
TOP1TOP1mtTOP1TOP1mtTOP1TOP1mtTOP1TOP1mt
 133 (280)0330
 225131,938
 397214,680
 412401,287
 55622,447
 6962984
 77603,221
 81107122 (141)27227,9033,400
 9211611660114,6321,752
10312212265008733,005
11412312362001,718688
1251881887522965716
136145145640011,428342
14714414470001,0442,612
15818618675001,215>2,500
16969697200838180
171011511572111,7761,596
181112812871003,399177
191295956422215>5,000
201315015067221,039524
2114103 (1298)103 (184)75
  • Exon and intron sizes are in bp. For exons 1 and 14 of TOP1mt, and exons 1 and 21 of TOP1, sequence lengths given inside parentheses include noncoding regions. Sizes given without parentheses are for the coding regions, which were used for homology calculation. Intron sizes for TOP1 were derived from the National Center for Biotechnology Information (NCBI) database. Intron sizes of the TOP1mt gene are based on the human genome data (NCBI database) and sequencing data from our genomic clone (GenBank accession nos. AF349018AF349031).