Table 2

Effect of short-term E treatment on mammary carcinogenesis

TreatmentNo. of rats with cancer per no. of ratsPercent of rats with mammary cancerAverage no. of cancers per rat
Control11/111003.0  ± 0.5
20 μg of E8/11731.2  ± 0.4*
100 μg of E2/1217**0.6  ± 0.4**
200 μg of E2/1217**0.3  ± 0.2**
30 mg of E2/1217**0.2  ± 0.1**
  • Effect of different doses of E on mammary carcinogenesis. Rats were treated with MNU at 7 weeks of age. At 9 weeks of age, the rats were treated with various doses of E for 3 weeks. 

  • * , P < 0.05; 

  • ** , P < 0.01; 

  • ** , P < 0.001 (compared to control).