Table 1

Ion channels associated with multi-PDZ domain proteins

Ion channelScaffold protein (number of PDZ domains)Reference
NMDA receptorsPSD-95 (3)(20)
SAP-102 (3)(21)
AMPA receptorsGRIP1 (7)(22)
PICK-1 (1*)(23)
SAP97 (3)(24)
Shaker K+ channelsPSD-95 (3)(25)
Dlg-1 (3)(26)
TRPINAD (5)(27)
Ca2+ channelsMint-1 (2)(28)
CFTRCAP70 (4)(5)
NHERF (2)(6)
Kir4.1 K+ channelsCIPP1 (4)(29)
ENaCPICK1 (1*) †
  • NMDA, N-methyl-d-aspartate; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid. TRP, transient receptor potential. 

  • * PICK1 protein forms oligomers via PICK1–PICK1 interactions (23). 

  • Hruska-Hageman, A. M., Price, M. P., Johnson, W. A. & Welsh, M. J. (2000) J. Neurosci. 26, 1906 (abst.).