Table 1

Kinin-forming activity and endogenous bradykinin level in organs and fluids of TK+/− and TK−/− mice as compared with TK+/+ mice

StrainKinin-forming activity Endogenous bradykinin
pg of BK/h per μg of protein ng of BK/min per 24-h excretion fmol/g of tissue
Kidneys, n = 7Colon, n = 7Pancreas, n = 15Salivary glands, n = 7Heart, n = 7Urine, n = 6Feces, n = 14Kidneys, n = 16Heart, n = 16
+/+32.6  ± 6.132.7  ± 11.55,077  ± 1,364518,743  ± 114,9781.6  ± 1.12,384  ± 1641,708  ± 4529.2  ± 1.4<X
+/−12.3  ± 2.411.6  ± 5.31,846  ± 805118,800  ± 19,6970.8  ± 0.6887  ± 173958  ± 334NMNM
−/−1.2  ± 0.41.8  ± 1.014  ± 27,629  ± 1,8561.2  ± 0.410  ± 117  ± 22.1  ± 0.5<X
P 0.00010.020.00080.00010.560.00010.0020.0001NA
  • The detection limit X of endogenous bradykinin (BK) was 1.3 fmol/g of tissue. Values (means ± SEM) have been compared by ANOVA. NM, not measured; NA, not applicable.