Table 2

Relative frequency of the common BRCA1 and BRCA2 mutations in Ashkenazi Jewish subjects and families affected with breast/ovarian cancer

Study subjectsNumberAffected BRCA1 carriers, %Affected BRCA2 carriers, %Ref.
Unselected living breast cancer cases41234  (8.3%)15  (3.6%) 23
Unselected breast cancer cases, pathology slides26810  (3.7%)8  (3%)6
Unselected ovarian cancer cases20857  (27%)29  (14%) 24
Selected breast cancer cases17816  (9%)8  (4.5%) 25
Breast and breast/ovarian families22091  (41%)9  (4%) 26
Families with known BRCA1/BRCA2 mutations205141  (69%)64  (31%)This study
Breast or ovarian cancer survivors among Jewish volunteers30216  (5.3%)11  (3.6%)5