Table 5

Comparison of reactivities with sulfhydryl groups and potencies in elevating GSH of bis(benzylidene)acetone derivatives in three cell types

Acetone derivativesk2 for reaction, M−1⋅sec−1Conc. that elevates GSH by 50%, μM
With DTTWith GSHHepa 1c1cPEHaCaT
Bis(benzylidene)- (22)0.4170.1453.75.31.5
Bis(2-hydroxybenzylidene)- (23)2.505.00.0750.40.13
Bis(4-hydroxybenzylidene)- (24)0.0140.0016.0>102.1
  • DTT, dithiothreitol.