Table 1

Reduction in mouse tumor number and genotypes

StrainsPLA2cPLA2COX-2% reduction
ApcMin alone−/−+/++/+0
ApcMinMom1AKR/B6+/−+/++/+50*
ApcMin SPLA2 Tg+−/− tg++/++/+28*
ApcΔ716 COX-2−/−−/−+/+−/−86
ApcMincPLA2−/−−/−−/−+/+83
  • Percent reduction in tumor number and genotypes of various mouse strains relative to ApcΔ716 (COX-2 deletion) or ApcMin (all others). All strains were analyzed on a C57BL/6 background. 

  • * See ref. 9

  • See ref. 10