Table 5

Elimination of group A streptococci from the mucosal surface of colonized mice (500 units lysin/mouse)

MouseStrep (107) ↓Day 1Day 2Day 3Day 4Lysin ↓ Postlysin treatment
Day 4, 2 hrDay 5, 24 hrDay 6, 48 hr
1>300>300>300>30000200*
2>300>300>300>300050*0
3>300>300>300>300000
4>300>300>300>300000
5>300>300>300>3000DeadDead
6>300>300>300>3000n.d.0
7>300>300>300>3000n.d.0
8>300>300>300>3000n.d.0
9>300>300>300>3000n.d.0
Total colonized9/99/99/99/90/92/52/9
  • n.d., no data collected; indicated numbers are cfus.. 

  • * Isolated streptococci remained sensitive to lysin treatment in vitro.