Table 1

Effects of treatment with CNTFAx15 (C-0.1 or 1.0 mg/kg/day s.c. for 7 days) or pair feeding (PFC-0.1) on change in body weight, serum levels, and activity in DIO mice

TreatmentBW, % changeInsulin, pg/mlTriglycerides, mg/dlActivity, %Corticosterone, ng/ml
lean−3.6  ± 1*680  ± 175*137  ± 1694.6  ± 0.633  ± 10*
DIO−3.9  ± 1.2*2701  ± 564146  ± 1290.4  ± 1.528  ± 5*
DIO + C-0.1−14.3  ± 0.61103  ± 234*67  ± 3*89.9  ± 1.638  ± 5*
DIO + PFC-0.1−11.2  ± 0.32846  ± 887126  ± 491.3  ± 192  ± 26
DIO + C-1.0−32.9  ± 1.3*683  ± 227*42  ± 9*83.2  ± 4*118  ± 22
  • Mean ± SEM (n = 7) for change in body weight, serum level of insulin, triglycerides, corticosterone, and locomotor activity are shown. ANOVA: percentage of BW, P < 0.0001; insulin, P < 0.01; triglycerides, P < 0.0001; corticosterone, P < 0.001; and activity, P < 0.05. 

  • * Difference from PFC-0.1 by Dunnett post hoc test. 

  • Difference from ad libitum fed DIO control by Dunnett post hoc test.